Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study

Launched by CENTRE PAUL STRAUSS · Jul 7, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how chemotherapy treatment for breast cancer affects the way the body controls heart and blood vessel function during exercise. Chemotherapy can make it harder for patients to exercise because it impacts the heart and muscles, causing a type of fatigue linked to how certain nerves send signals during physical activity. The study will use simple, non-invasive tests to measure how these nerves and blood pressure control systems are working in women who have recently finished chemotherapy, comparing them to healthy women of similar age and fitness.

Women who have been treated for early to mid-stage breast cancer (Stage I to III) and completed their chemotherapy within the last three weeks may be eligible to join. Healthy women without a history of cancer and with similar age and activity levels can also participate as a comparison group. Participants will undergo safe and painless tests that involve mild exercise and temporary changes in blood flow to help researchers understand how chemotherapy affects cardiovascular health. The goal is to use this information to create personalized exercise programs that can help improve heart and muscle function and reduce side effects after treatment.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• Patient group :
• • Stage I to III breast cancer
• • Having completed (neo)adjuvant chemotherapy treatment less than three weeks ago
• Control group :
• • - healthy women (no history of cancer) of similar age, weight, and physical activity level
• Exclusion Criteria:
• • History of cancer
• • Any known chronic pathology
• • Protected minor or adult
• • Psychiatric, musculoskeletal or neurological problems
• • Implantation of a pacemaker
• • Pregnant woman
• • Presenting at least one contraindication to the use of transient blood flow occlusion