Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant

Launched by CHIESI POLAND SP. Z O.O. · Jul 15, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how doctors can use bedside ultrasound—a safe, painless imaging test done right at the baby’s bedside—to better care for premature newborns who have trouble breathing due to a condition called Respiratory Distress Syndrome (RDS). The study is looking at whether using ultrasound images of the lungs, along with oxygen levels, can help doctors decide when and how to give a medicine called surfactant, which helps the baby’s lungs work better. Some babies will also have their heart and lung blood flow checked to see if there are signs of high blood pressure in the lungs.

The trial will include about 200 premature babies born before 37 weeks of pregnancy who have or might develop RDS. Babies with major lung abnormalities or those needing immediate breathing machines right after birth won’t be included. During the study, doctors will perform ultrasound scans before and after giving surfactant to see how both lungs respond and if this affects the baby’s need for breathing support. The goal is to find better ways to treat newborns with breathing problems and improve their care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Preterm neonates (gestational age \<37 weeks) with established Respiratory Distress Syndrome (RDS) or at risk for RDS
• • Decision of the use of surfactant by the attending physician
• Exclusion Criteria:
• • Presence of major congenital abnormalities of the respiratory system
• • Infants requiring primary intubation and mechanical ventilation in the delivery room