Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Launched by EGAS MONIZ - COOPERATIVA DE ENSINO SUPERIOR, CRL · Jul 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help treat periodontitis, which is a serious gum disease caused by harmful bacteria around the teeth. The trial looks at using photodynamic therapy (PDT) alongside the usual deep cleaning treatment (called scaling and root planing). PDT uses a special light-activated medicine that helps kill bacteria more effectively without harming healthy tissues. The goal is to see if adding this light therapy can improve healing, reduce bacteria better, and possibly avoid more invasive treatments.

Adults with periodontitis who have at least 10 teeth and haven’t had recent gum treatment, antibiotics, or certain medications may be eligible to join. People with diabetes, pregnant or breastfeeding women, or those with very severe gum damage are not included. Participants will receive the standard cleaning treatment, and some will also get the light-based therapy. This study is currently looking for volunteers and aims to find safer, more effective ways to manage gum disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria and with at least 10 teeth in the mouth.
• Exclusion Criteria:
• • Periodontal treatment in the previous six months; use of antibiotics, NSAIDs or immunosuppressants in the previous six months; acute oral infection; pregnant or breastfeeding women; teeth with grade III mobility; pockets with PD \> 10 mm; use of antimicrobial mouthwash in the previous two months; patients with diabetes mellitus.