Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure

Launched by RIJNSTATE HOSPITAL · Jul 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how treating blockages in certain large blood vessels near the belly (called the aorto-iliac arteries) can affect blood pressure. Sometimes, these arteries become narrowed, making it harder for blood to flow and causing high blood pressure. Doctors often use tiny tubes called stents to open these blocked arteries. This study wants to see if placing stents in these specific arteries can lower blood pressure and reduce strain on the heart.

To join the study, participants need to be adults with a long-lasting blockage in the main artery below the kidneys or in one or both of the large arteries leading to the legs. They should have symptoms like severe leg pain or poor blood flow that hasn’t improved with exercise. People who can’t follow the study instructions or who have certain other artery problems won’t be eligible. Participants will receive stent treatment and will be followed to see how their blood pressure changes afterward. This study is just starting and aims to help doctors better understand how fixing these blockages might improve heart health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years
• • Singed informed consent
• • Chronic occlusion in the infrarenal aorta and/or one or both common iliac arteries
• • Total lesion length of ≥30mm
• • Clinical indication for treatment of the pathology (Chronic limb threatening ischemia or disabling intermittent claudication not responding to supervised exercise training)
• Exclusion Criteria:
• • Patient is unable to understand the study requirements and/ or is unwilling to adhere to the follow-up
• • Juxtarenal pathology (\<2cm below the lowest renal artery)
• • Acute occlusion of the target area (Acute Leriche Syndrome)
• • Embolic disease