Indomethacin vs Diclofenac for Preventing PEP

Launched by AIR FORCE MILITARY MEDICAL UNIVERSITY, CHINA · Jul 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two medicines, indomethacin and diclofenac, to see which one works better at preventing pancreatitis—a painful inflammation of the pancreas—that can happen after a procedure called ERCP. ERCP is a test to look at the tubes that carry bile and pancreatic juice, but sometimes it can cause pancreatitis, which can lead to longer hospital stays and other problems. Both medicines are types of anti-inflammatory drugs given as a suppository (a small pill placed in the rectum) before the procedure to lower the risk of pancreatitis. While both have been shown to help, it’s not clear which one is better, so this study aims to find out.

Adults between 18 and 80 years old who are scheduled for ERCP and have not had certain earlier procedures on their bile ducts may be eligible to join. People who have allergies to these medicines, recent pancreatitis, certain health problems like kidney issues or bleeding, or who are pregnant cannot take part. If you join, you will receive one of the two medicines before your ERCP, but neither you nor the doctors will know which one you are getting until the study is over. The goal is to see which drug better prevents pancreatitis after ERCP, helping doctors choose the safest and most effective treatment for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-80 years old patients with native papilla who planned to undergo ERCP
• Exclusion Criteria:
• • Previous biliary sphincterotomy and papillary large balloon dilation
• • Planned for placements of pancreatic duct stents (eg. pancreatic duct strictures, planned ampullectomy)
• • Allergy to NSAIDs
• • The administration of NSAIDs within 7 days
• • Not suitable for NSAIDs administration (gastrointestinal hemorrhage within 4 weeks, renal dysfunction \[Cr \>1.4mg/dl=120umol/l\]; presence of coagulopathy before the procedure)
• • Acute pancreatitis within 7 days before ERCP or acute pancreatitis with obvious Pancreatic edema and peripancreatic fluid collections
• • Hemodynamical instability
• • Pregnancy or lactation
• • Unable to give informed consent