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Search / Trial NCT07073235

Effects of iTBS on Motor Recovery of Lower Extremity in Chronic Stroke Patients.

Launched by DANDERYD HOSPITAL · Jul 9, 2025

Trial Information

Current as of July 24, 2025

Not yet recruiting

Keywords

Stroke I Tbs Tms Trancranial Magnetic Stimulation Cerebellum Chronic Stroke Patients Balance Walking Hemiparesis

ClinConnect Summary

This clinical trial is studying a new way to help people recover movement in their legs after having a stroke. It uses a special, non-invasive brain stimulation technique called intermittent Theta Burst Stimulation (iTBS) to see if it can improve walking and leg strength for people who have had a stroke more than six months ago. The study also looks at how this treatment may change brain activity and connections to better understand how recovery happens.

People who might join this study are adults over 18 who have had a stroke at least six months ago and still have some weakness in their legs but can walk with some support. The trial is open to both men and women. Participants will receive brain stimulation as part of their rehabilitation, and the researchers will carefully check how their brain and leg function change over time. Some people won’t be able to join, like those with metal implants, epilepsy, severe memory problems, or other health issues that make physical training difficult. This study is not yet recruiting participants but aims to offer new hope for improving leg movement after stroke.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Age over 18
  • Chronic stroke (\>6 months)
  • Residual hemiparesis FAC ≥3
  • Exclusion Criteria:
  • Metal implants
  • Epilepsy/seizures
  • Pregnancy
  • Claustrophobia (related to MRIs exams)
  • Severe cognitive impairment
  • Untreated or unstable depression/anxiety
  • Other disabilities prohibiting intensive physical training

About Danderyd Hospital

Danderyd Hospital is a leading medical institution in Sweden, renowned for its commitment to advancing healthcare through innovative clinical research and trials. As a prominent sponsor of clinical studies, the hospital leverages its extensive expertise and state-of-the-art facilities to facilitate groundbreaking research across various medical disciplines. Danderyd Hospital collaborates with academic institutions, industry partners, and healthcare professionals to enhance patient care and contribute to the development of new therapies and treatments. With a focus on ethical standards and patient safety, Danderyd Hospital aims to improve health outcomes and drive medical advancements that benefit the wider community.

Locations

Stockholm, , Sweden

Patients applied

0 patients applied

Trial Officials

Susanne Palmcrantz, PhD, Associate Professor

Principal Investigator

Dep of Clinical Sciences, Karolinska Institutet

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported