Viscoelastic Coagulation for Early Sepsis Detection

Launched by HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to detect sepsis early in adults who come to the emergency room with a possible infection. Sepsis is a serious condition where the body’s response to infection can cause organ damage. The researchers want to see if a special blood test called Viscoelastic Coagulation Monitoring (VCM), which looks at how blood clots, can help predict who might develop sepsis soon after arriving at the hospital. They will check several blood clotting measurements to find patterns that might signal a higher risk for sepsis.

Adults aged 18 and older who are suspected of having an infection may be eligible to join, as long as they haven’t taken certain blood-thinning or immune medications recently and don’t have specific health conditions like cancer or blood disorders. If you join, a blood sample will be taken when you arrive at the emergency room, and if admitted to the hospital, blood will be collected daily for up to three days. If you are sent home, someone from the study team will call you for three days to check how you’re doing. This study is currently recruiting patients at ATTIKON University General Hospital and aims to help doctors find better ways to spot sepsis early, which can improve treatment and outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults male or female (age 18 years or more)
• • Suspicion of infection, defined according to medical judgment
• Exclusion Criteria:
• • Age less than 18 years
• • Denial for consent
• • Intake of any anti-coagulant medication the last one month
• • Intake of any anti-platelet medication the last one month
• • Intake of any biological disease modifying anti-rheumatic medication the last one month
• • Medical history of inflammatory bowel disease or pulmonary hypertension
• • Any medical history of hemophilia or congenital coagulation disorders
• • Any known solid tumor or hematologic malignancy irrespective the stage and treatment
• • Known infection by the hepatitis viruses B and C
• • Known infection by the human immunodeficiency virus
• • Pregnancy or lactation