Viscoelastic Coagulation Monitoring for Early Sepsis Detection
Launched by HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS · Jul 9, 2025
Trial Information
Current as of July 23, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new way to detect sepsis early in adults who come to the emergency room with a possible infection. Sepsis is a serious condition where the body’s response to infection can cause organ damage. The researchers want to see if a special blood test called Viscoelastic Coagulation Monitoring (VCM), which looks at how blood clots, can help predict who might develop sepsis soon after arriving at the hospital. They will check several blood clotting measurements to find patterns that might signal a higher risk for sepsis.
Adults aged 18 and older who are suspected of having an infection may be eligible to join, as long as they haven’t taken certain blood-thinning or immune medications recently and don’t have specific health conditions like cancer or blood disorders. If you join, a blood sample will be taken when you arrive at the emergency room, and if admitted to the hospital, blood will be collected daily for up to three days. If you are sent home, someone from the study team will call you for three days to check how you’re doing. This study is currently recruiting patients at ATTIKON University General Hospital and aims to help doctors find better ways to spot sepsis early, which can improve treatment and outcomes.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adults male or female (age 18 years or more)
- • Suspicion of infection, defined according to medical judgment
- Exclusion Criteria:
- • Age less than 18 years
- • Denial for consent
- • Intake of any anti-coagulant medication the last one month
- • Intake of any anti-platelet medication the last one month
- • Intake of any biological disease modifying anti-rheumatic medication the last one month
- • Medical history of inflammatory bowel disease or pulmonary hypertension
- • Any medical history of hemophilia or congenital coagulation disorders
- • Any known solid tumor or hematologic malignancy irrespective the stage and treatment
- • Known infection by the hepatitis viruses B and C
- • Known infection by the human immunodeficiency virus
- • Pregnancy or lactation
About Hellenic Institute For The Study Of Sepsis
The Hellenic Institute for the Study of Sepsis is a leading research organization dedicated to advancing the understanding and treatment of sepsis through innovative clinical trials and interdisciplinary collaboration. Committed to improving patient outcomes, the Institute conducts high-quality research that focuses on the prevention, diagnosis, and management of sepsis, fostering partnerships with healthcare professionals, academic institutions, and industry stakeholders. By translating scientific discoveries into clinical practice, the Hellenic Institute aims to enhance the standard of care for patients at risk of sepsis and contribute to global efforts in combating this critical condition.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chaidari, Attiki, Greece
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported