Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation

Launched by LEEDS BECKETT UNIVERSITY · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether taking a daily probiotic supplement called Lab4P can help improve thinking skills and overall health in young adults who are overweight and have early signs of blood sugar problems (called impaired glucose tolerance or “prediabetes”). The study will look at changes in memory, focus, and how quickly the brain processes information, as well as how well the body controls blood sugar, heart health, cholesterol, body fat, and inflammation. Researchers will also check if the probiotic affects gut bacteria and make sure it is safe to use.

The study is for adults aged 18 to 35 who are overweight (with a body mass index between 25 and 29.9) and generally healthy. To join, participants must not have diabetes or certain other health conditions, and they need to be able to follow study instructions like fasting before tests. If you join, you’ll take either the probiotic or a placebo (a harmless pill with no active ingredients) every day for 12 weeks, without knowing which one you’re taking. Throughout the study, your memory and thinking, blood sugar, heart function, and other health markers will be checked. This trial is not yet recruiting but aims to find out if probiotics might offer a simple way to support brain and metabolic health in young adults at risk for diabetes.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Aged 18-35 years
• • Body Mass Index (BMI) between 25.0 and 29.9 kg/m² (classified as overweight)
• • In good general health (self-reported)
• • Normal self-reported sleep patterns, with no history of diagnosed sleep disorders
• • Willing and able to provide informed consent
• • Able to comply with study procedures, including fasting and oral glucose tolerance testing
• Exclusion Criteria:
• • Diagnosed diabetes (any type).
• • Diagnosed sleep disorders.
• • Fasting glucose \>6.9 mmol/L during screening.
• • History of bariatric surgery (e.g., gastric bypass, sleeve gastrectomy).
• • Major surgery, significant illness, trauma, infection, or myocardial infarction within the past 6 weeks.
• • Current use of medications affecting glucose metabolism or probiotics
• • Pregnancy or actively trying to conceive
• • Night shift work within the past month