Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit

Launched by KANUNI SULTAN SULEYMAN TRAINING AND RESEARCH HOSPITAL · Jul 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain heart measurements can help doctors predict if patients in the intensive care unit (ICU) will successfully come off mechanical breathing machines. Specifically, it looks at how well the right side of the heart is working by using a simple ultrasound test called transthoracic echocardiography (TTE). Doctors will measure different heart functions to see if these can show who is ready to breathe on their own without needing the breathing machine again.

Adults in the ICU who are stable and ready to be taken off the breathing machine may be eligible to participate. Before the breathing tube is removed, they will have an ultrasound of their heart within two hours to check specific heart measurements. After the tube is removed, staff will watch them closely for 24 hours to see if they continue to breathe well without extra help. This study aims to help improve care by identifying which patients are more likely to successfully stop mechanical ventilation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Receiving invasive mechanical ventilation in the ICU
• • Planned extubation (weaning) according to standard clinical criteria
• • Hemodynamically stable at the time of transthoracic echocardiography (TTE)
• • Ability to undergo echocardiographic assessment within 2 hours prior to extubation
• • Informed consent obtained from patient or legal representative
• Exclusion Criteria:
• • Known severe tricuspid valve disease or congenital heart disease
• • Moderate to severe pericardial effusion or cardiac tamponade
• • Inadequate acoustic window for transthoracic echocardiography
• • Patients requiring urgent or unplanned extubation
• • Use of extracorporeal life support (e.g., ECMO) at the time of assessment
• • Known pulmonary embolism or acute cor pulmonale
• • Pregnancy