Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Launched by ASSIUT UNIVERSITY · Jul 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to predict if a common breathing support method called non-invasive ventilation (NIV) will stop working in patients with Chronic Obstructive Pulmonary Disease (COPD) during a flare-up. NIV helps people with COPD breathe better without needing a breathing tube, but sometimes it doesn’t work, and patients may need more intensive treatment. The researchers want to see if a measurement called the Volume Oxygenation (VOX) index can help doctors identify early on when NIV might fail, so they can adjust treatment sooner and improve patient care.

Patients who have COPD and are admitted to the respiratory intensive care unit (ICU) to receive NIV may be eligible to join the study, as long as they don’t need an immediate breathing tube. If you participate, your care team will measure your breathing and oxygen levels to calculate the VOX index within the first couple of hours of starting NIV. This study is not yet recruiting, but it aims to help doctors better predict treatment success and avoid delays in providing the right support for COPD patients during flare-ups.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All patients diagnosed with COPD admitted to the respiratory ICU for NIV.
• Exclusion Criteria:
• • Patients indicated for urgent intubation