Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit

Launched by KANUNI SULTAN SULEYMAN TRAINING AND RESEARCH HOSPITAL · Jul 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well the heart’s function can help predict if a patient in the intensive care unit (ICU) will be successfully taken off a breathing machine (mechanical ventilation). Specifically, doctors will use a type of ultrasound called transthoracic echocardiography (TTE) to look at different heart measurements shortly after a patient is ready to try breathing on their own. The goal is to see if these heart measurements can tell us who will do well after the breathing tube is removed and who might need help again.

Adults who are currently on a breathing machine in the ICU and are about to start the process of being taken off it may be eligible for this study. To join, patients need to be stable and have met the usual criteria for weaning from the ventilator. During the study, participants will have a quick, painless heart ultrasound within two hours of meeting these criteria. After the breathing tube is removed, they will be watched closely for 24 hours to see if they can stay off the machine or if they need extra breathing support again. This research could help doctors make better decisions about when to safely remove breathing support, potentially reducing complications and hospital stays for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Currently receiving mechanical ventilation in the ICU
• • Planned extubation after meeting standard weaning criteria
• • Hemodynamically stable at the time of echocardiographic evaluation
• • Written informed consent obtained from the patient or legally authorized representative
• Exclusion Criteria:
• • Surgery within the previous 24 hours
• • Presence of significant valvular heart disease or known cardiomyopathy
• • Inadequate acoustic window for transthoracic echocardiography
• • Ongoing use of extracorporeal support (e.g., ECMO)
• • Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours
• • Re-intubation planned prophylactically regardless of clinical status
• • Pregnant patients