Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males

Launched by SOHAG UNIVERSITY · Jul 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between testosterone levels in the blood and the complexity of blockages in the heart’s arteries in men under 45 years old who have early signs of heart disease. The researchers want to understand if testosterone plays a role in how severe the artery problems are, which could help improve how these patients are diagnosed and treated.

Men younger than 45 who have been diagnosed with early heart disease and are scheduled for a special heart test called coronary angiography (which looks at the arteries in the heart) may be able to join this study. Participants should not have had a recent heart attack, hormone-related conditions, or certain other health problems like liver or kidney disease. If you take part, you can expect to have your blood tested for testosterone levels and your heart arteries carefully examined during the angiography. This study is currently looking for volunteers, and it could provide important information about heart disease in younger men.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male patients aged \<45 years.
• • Diagnosed with premature ischemic heart disease.
• • Undergoing elective coronary angiography for suspected coronary artery disease (CAD) .
• Exclusion Criteria:
• • History of acute coronary syndrome within the preceding 3 months.
• • Prior diagnosis of hypogonadism or history of testosterone replacement therapy or anabolic steroid use.
• • Active neoplasm or history of chemotherapy.
• • Known hepatic cirrhosis, chronic kidney disease, or end-stage renal disease.
• • Use of medications known to affect sex hormone levels (e.g., spironolactone, ketoconazole).
• • Endocrine disorders such as sickle cell anemia or celiac disease.