Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols

Launched by NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS · Jul 11, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how different ways of cleaning teeth below the gumline—called non-surgical periodontal therapy—might affect the body’s overall inflammation and the presence of bacteria in the blood. Periodontitis, a serious gum disease, not only damages the tissues that support your teeth but can also cause low-level inflammation throughout the body. This inflammation is linked to other health problems like heart disease and diabetes. The study will compare five different cleaning methods to see which one causes the least amount of bacteria to enter the bloodstream and how each method affects inflammation levels in both blood and saliva. The trial will also check how well each treatment improves gum health.

People who might join this study are adults with moderate to severe periodontitis (stage III or IV), who don’t smoke or only smoke lightly, haven’t had recent gum treatments or taken certain medications, and don’t have other infections or health conditions that affect inflammation. Pregnant or breastfeeding women cannot take part. If you join, you can expect to receive one of five cleaning treatments, and the researchers will monitor your blood and saliva before and after treatment to see how your body responds. This study aims to find the safest and most effective way to treat periodontitis while minimizing any short-term risks to your overall health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Periodontitis stage III or IV
• • Non-smokers or light smokers (\<10 cigarettes/day)
• • No NSAIDs in regular basis or antibiotics 3 months before
• • No previous periodontal treatment 12 months before
• • No presence of other acute or chronic infections
• • No systemic disease or medication known to affect the serum level of inflammatory markers (cyclooxygenase inhibitors, platelet aggregation inhibitors, lipid lowering agents, â-adrenoreceptor antagonists, angiotensin converting enzyme inhibitors, antidiabetic agents, estrogen-based medications, medication for autoimmune disease, magnesium or vitamin E supplements)
• • No pregnancy or lactation
• • Written informed consent.