The Danish Bladder Cancer Group 23 Study - A Nordic Study on Cancer in the Upper Urinary Tract

Launched by ZEALAND UNIVERSITY HOSPITAL · Jul 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a rare type of cancer called upper urinary tract urothelial carcinoma (UTUC), which affects the kidney area and the tube that carries urine from the kidney to the bladder. The usual treatment involves removing the entire kidney and ureter, but recent guidelines suggest that some patients with less risky tumors might safely keep their kidney through a less aggressive surgery called kidney-sparing surgery. This study wants to find out if more patients can benefit from this kidney-preserving approach without increasing the chance of the cancer coming back, while also keeping a good quality of life. The research will also look at how kidney function changes over time, the risk of developing bladder cancer after treatment, and how UTUC behaves in patients with a genetic condition called Lynch syndrome.

Anyone aged 18 or older who has been diagnosed with UTUC can join the study, as long as they agree to participate. Participants’ medical information will be collected when they join and again after 1, 3, 5, and 10 years. People in Denmark will also be asked to complete questionnaires about their quality of life during the first five years. This study is not yet recruiting, but it aims to better understand who can safely have kidney-sparing surgery and to improve care for patients with this rare cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with confirmed histopathology of UTUC
• • Age ≥ 18 years
• • Informed patient consent
• Exclusion Criteria:
• • Patient not willing or able to give informed consent