Natriuresis-guided Depletion After Cardiac Surgery

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Jul 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to manage fluid buildup, called fluid overload, which often happens after heart surgery. Usually, doctors use a medicine called furosemide to help remove extra fluid, but the amount given is based on experience rather than precise measurements. This study will test if using a special sensor to measure salt (sodium) in the urine can guide how much furosemide is given, potentially making fluid removal safer and more effective after surgery.

Adults who are having certain types of heart surgery that require a heart-lung machine, like valve repairs or bypass surgery, may be eligible to join. Participants will receive the usual care but with the added use of the urine sensor to help adjust their treatment. The trial will look at how well this method works, how safe it is, and whether it can be easily used in hospitals. If you or a loved one is planning to have heart surgery and meets the criteria, this study might offer a new approach to managing fluid after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patient (age \> 18 years)
• • Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures
• • Undergoing surgery with cardiopulmonary bypass (CPB)
• • Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician
• • Written and oral informed consent obtained
• • Covered by the French national health insurance (Sécurité Sociale)
• Exclusion Criteria:
• • Aortic arch repair requiring deep hypothermic circulatory arrest
• • Active endocarditis
• • Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)
• • Failure to wean from CPB requiring mechanical circulatory support
• • Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \< 60 mL/min
• • Chronic use of loop diuretics
• • Known allergy to furosemide
• • Active postoperative bleeding and/or reoperation for bleeding
• • Participation in another interventional study that may affect the primary outcome measure
• • Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)