ROS-scavenging Amino Acid-derived Lipids for the Prevention and Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer

Launched by WEST CHINA HOSPITAL · Jul 15, 2025

Keywords

ClinConnect Summary

This clinical trial is testing a new treatment to help prevent and reduce skin problems caused by radiation therapy in patients with head and neck cancer. Radiation dermatitis is a common side effect where the skin becomes red, sore, or damaged from the radiation used to treat the cancer. The study is looking at a special lotion made from natural amino acid-based lipids that can help protect the skin by fighting harmful molecules that cause damage during radiation. Researchers want to see if this lotion is safe to use and if it can lower the severity of skin irritation, helping patients complete their cancer treatment more comfortably.

People who may join this study are adults diagnosed with certain head and neck cancers that have not spread to other parts of the body, and who are about to start or continue high-dose radiation therapy, either as the main treatment or after surgery. Participants should not have existing skin problems or allergies related to the lotion’s ingredients, and they should be in generally good health to undergo treatment. While this study is not yet enrolling patients, those who participate will use the lotion during their radiation therapy and be monitored to see how well it works and if it causes any side effects. This trial could offer a new way to protect the skin and improve the overall experience of cancer treatment.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with a pathological diagnosis of non-metastatic head and neck malignant tumors;
• • 2. Patients deemed suitable for high-dose radiotherapy, either as a primary treatment or as postoperative treatment following surgical resection.
• Exclusion Criteria:
• • 1. Eastern Cooperative Oncology Group performance status of \>2;
• • 2. Pre-existing skin rash, ulceration or open wound in the treatment area;
• • 3. Known allergy to trolamine or amino acid;
• • 4. Inflammatory or connective tissue disorder of the skin;
• • 5. History of head and neck radiotherapy.