Cohort of Patients With Ulcerative Colitis or Polyps Followed in CHU de Bordeaux Associated With a Biocollection - COLIBRI

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jul 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying people with ulcerative colitis (UC), a long-term condition that causes episodes of bloody diarrhea and inflammation in the colon. The researchers want to better understand how UC changes over time, especially during severe flare-ups that can be very serious. They believe that differences in how the body and gut bacteria interact may explain why some people have more severe symptoms than others. To learn more, they will follow patients with UC for one year to observe how the disease progresses.

The study is open to adults (18 years and older) who speak French and have been diagnosed with UC according to official guidelines. Participants will either be having a colon exam or surgery related to their condition. People with certain other bowel diseases, pregnant or breastfeeding women, and those unable to give informed consent cannot join. If you take part, you can expect to be closely followed by the medical team over the year to better understand your condition. This trial is not yet recruiting, but it aims to improve knowledge that could help manage UC more effectively in the future.

Gender

ALL

Eligibility criteria

• * Inclusion criteria:
• * General Inclusion Criteria:
• • Patients covered by a social security system.
• • French-speaking patients.
• • Patients aged ≥18 years.
• • Patients who have provided free, informed, and written consent (no later than the inclusion day and before any research-related examination).
• * Specific Inclusion Criteria for the UC Group:
• • Patients diagnosed with ulcerative colitis (UC) according to the European Crohn's and Colitis Organisation (ECCO) guidelines.
• • Patients undergoing lower gastrointestinal endoscopy or rectocolic surgery.
• * Non-UC Patients with Polyps Group:
• • Patients undergoing colonoscopy with resection of hyperplastic polyps in the rectum, sessile serrated lesions, or adenomas \>2 cm.
• * Exclusion criteria:
• • Patients with perianal, ileal lesions, or endoscopic features of colonic lesions suggestive of Crohn's disease.
• • Pregnant or breastfeeding women.
• • Patients under legal protection or unable to provide informed consent.
• • Patients deprived of liberty by judicial or administrative decision, hospitalized without consent, or admitted to a healthcare or social institution for reasons unrelated to the study.