Acute Kidney Injury in Neonatal ICU in Assuit University

Launched by ASSIUT UNIVERSITY · Jul 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying acute kidney injury (AKI) in newborn babies who are cared for in the neonatal intensive care unit (NICU). AKI happens when the kidneys suddenly stop working properly, which can lead to problems with removing waste and balancing fluids in the body. Newborns, especially those who are very sick or born early, are at higher risk for this condition. The study aims to better understand how often AKI occurs in these babies, how to diagnose it early, and how to improve their care to prevent long-term kidney problems.

Babies who are between birth and 28 days old and show signs of AKI—such as low urine output or increased waste products in the blood—may be eligible for this study, as long as their parents agree to participate. Babies who have had recent surgery, major kidney abnormalities, or a family history of kidney failure will not be included. If enrolled, families can expect careful monitoring of the baby’s kidney function through tests like blood and urine checks. The goal is to catch kidney issues early and tailor treatment to each baby’s needs, helping to improve their chances of recovery and reduce complications.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Age from 0 to 28 days presented with acute kidney injury on based of raised renal chemistry, An increase in serum creatinine (e.g., \>0.3 mg/dL or \>50% from baseline) , Oliguria (urine output less than 1 mL/kg/h for more than 6 hours).
• • Other biomarkers of kidney injury (e.g., elevated urinary biomarkers such as NGAL, KIM-1) ( if available)
• • Parental consent: Neonates whose parents or legal guardians provide informed consent for participation in the study
• Exclusion Criteria:
• • • Post-operative neonates.
• • Cases with gross congenital anomalies of the kidney and urinary tract.
• • Neonates with a maternal history of kidney failure.