Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Launched by BETTINA MITTENDORFER · Jul 16, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on making sure that certain medical tests and tools used to study conditions like obesity, diabetes, heart disease, and bone or muscle problems give accurate and reliable results. The researchers want to check that when these tests or procedures—such as blood tests or inserting an intravenous (IV) line—are done multiple times, they produce consistent results. This is important because it helps scientists trust the information they get when studying chronic health issues and how the body processes nutrients.

People aged 18 to 100 years old with a body mass index (BMI) between 16 and 60 may be eligible to participate, as long as they don’t have certain health issues or lifestyle factors that could affect the tests, like allergies to certain foods, regular use of medications that might interfere, or heavy exercise routines. Participants can expect to undergo repeat testing to help the researchers confirm that the tests work well and provide consistent data. This study is not yet recruiting, and it includes both healthy individuals and those with relevant medical conditions. Importantly, the study excludes pregnant women, smokers, and people who cannot give informed consent.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥18 and ≤100 years of age
• • body mass index ≥16.0 and ≤60 kg/m2
• Exclusion Criteria:
• • \<18 and \>100 years of age
• • body mass index \<16.0 or \>60 kg/m2
• • allergies, intolerances, or dietary restrictions to meal ingredients, vegans or vegetarians
• • use of medications or dietary supplements (e.g., anti-inflammatories, immune modulators, etc) that could interfere with the particular assay/techniques being evaluated
• • engaged in regular structured exercise \>150 min per week unless needed for validation of the assay/technique being evaluated
• • significant organ system dysfunction or diseases, except those that are sought for validation of the assay/technique being evaluated
• • alcohol use disorder as defined by the National Institute of Alcohol Abuse and Alcoholism or use of controlled substances unless alcohol use disorder is required for validation of the assay/technique being evaluated
• • pregnant women, persons who smoke, prisoners, and inability to grant voluntary informed consent.