Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence

Launched by MINIA UNIVERSITY · Jul 16, 2025

Keywords

ClinConnect Summary

This study is looking at how two special cleaning methods combined with natural substances called nano-chitosan and aloe vera affect pain and complications after root canal treatment in teeth with a painful, inflamed nerve (a condition called acute pulpitis). The two cleaning methods being tested are called passive ultrasonic activation and laser activation, which help clean the inside of the tooth more effectively. Researchers want to see if using these methods can reduce pain and the chance of flare-ups after treatment.

Adults aged 18 to 60 with certain types of teeth—specifically, permanent teeth that have multiple roots and are healthy enough to be treated—may be eligible to join. To participate, the tooth must have a painful, inflamed nerve but no infection around the root tip, and the person should be generally healthy without other medical conditions like diabetes or high blood pressure. If you qualify, you would receive one of the cleaning methods during your root canal treatment and be asked to come back for follow-up visits to check your recovery and any pain after the procedure. This study isn’t recruiting yet, but it aims to find better ways to make root canal treatments more comfortable and successful.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-60 (adults only)
• • multiple-rooted with multiple root canal.
• • Permanent teeth with mature apex and complete root formation.
• • Without root caries.
• • Tooth must be restorable.
• • Without anatomical abnormalities such as fusion.
• • Healthy patient category I according to ASA.
• • Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis.
• • No periapical radiolucency.
• • Consent Patients for who consent to participate and attend follow-up appointments.
• Exclusion Criteria:
• • single root canals or double root.
• • Root canal calcifications.
• • Root resorption or fracture.
• • Previously root canal treated teeth.
• • immunocompromised patients.
• • Pregnant females
• • Patients with systemic diseases as diabetic or hypertension patients.
• • Patients with facial swelling.
• • patients who use analgesics or antibiotics within 48-72 hours.
• • Allergy to any materials used (e.g., irrigants or anesthetics).
• • psychiatric illness
• • Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.
• • Previously endodontically treated teeth.
• • Teeth with sinus tract.