Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients

Launched by GENERAL HOSPITAL OF SHENYANG MILITARY REGION · Jul 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to prepare the bowels for a colonoscopy in people with type II diabetes. Preparing the bowels well is very important for a clear and successful colonoscopy, but people with diabetes often have more trouble getting their bowels fully clean. This study will test whether combining two medicines—lactulose and polyethylene glycol (PEG)—can help improve bowel cleaning, reduce uncomfortable side effects like stomach pain or bloating, and still keep blood sugar levels steady.

Adults with type II diabetes who need a colonoscopy and agree to join the study may be eligible to participate. However, people with serious heart, lung, or liver problems, certain digestive issues, pregnancy, or allergies to the medicines won’t be able to join. If you take part, you can expect to follow a special bowel prep plan using the combination of lactulose and PEG before your colonoscopy. The goal is to make the bowel cleaning easier and more effective for diabetic patients, helping doctors get the best results during the exam.

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Eligibility criteria

• Inclusion Criteria:
• • 1. age 18\~75 years;
• • 2. patients undergoing colonoscopy;
• • 3. diagnosis of type II diabetes mellitus；
• • 4. sign the informed consent form.
• Exclusion Criteria:
• • 1. severe heart, lung or liver diseases;
• • 2. bowel resection;
• • 3. intestinal obstruction and massive ascites;
• • 4. women preparing for pregnancy or those who were pregnant and lactating;
• • 5. mental disorders;
• • 6. dysphagia;
• • 7. allergy to any medication used for bowel preparation;
• • 8. have used prokinetic agents (such as domperidone or mosapride) within 14 days prior to the colonoscopy;
• • 9. galactose or fructose intolerance, lactase deficiency, galactosemia, or glucose-galactose malabsorption syndrome.