The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN)

Launched by DONG ZHANG · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether giving extra nutrition through an IV (called supplemental parenteral nutrition or SPN) earlier during a stay in the intensive care unit (ICU) helps critically ill patients survive and recover better. Patients who are very sick, with one or more organ problems and who cannot get enough calories through their stomach or feeding tube within the first few days in the ICU, may benefit from this extra nutrition. The study compares starting this IV nutrition on day 4 versus starting it later on day 8, to see if earlier treatment improves survival and muscle strength, reduces infections, and helps patients recover better over time.

Adults who have been admitted to the ICU with serious organ issues, expected to stay in the ICU for more than three days, and who are not able to eat or absorb enough nutrition through normal feeding methods may be eligible to join. Participants will receive standard feeding plus the extra IV nutrition either early or later, and doctors will follow their progress in the hospital and for up to two years after. The goal is to find out if starting IV nutrition earlier can help patients live longer and regain their strength faster, though the effect on long-term quality of life is still being studied.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria：
• • 1. Age ≥ 18 years
• • 2. Failure of one or more organ systems within 24 hours of ICU admission, defined as Sequential Organ Failure Assessment (SOFA) score ≥ 2 in any single organ system
• • 3. Expected ICU stay \> 72 hours
• • 4. Able to initiate early enteral nutrition (EN) within 48 hours of ICU admission
• • 5. Enteral nutrition providing \<50% of target caloric requirements within 72 hour Exclusion Criteria
• • 1.Full oral intake or tolerance of full-dose EN; no need for SPN 2.Receiving palliative care or expected to die within 72 hours 3.Pregnant or lactating women 4.Long-term use of systemic corticosteroids or other immunosuppressive agents 5.Known malignancy currently receiving radiotherapy or chemotherapy 6.Contraindications to parenteral nutrition (PN) 7.Participation in another interventional clinical trial