Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery

Launched by ALEXANDRIA UNIVERSITY · Jul 18, 2025

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ClinConnect Summary

This clinical trial is comparing two medicines, dexamethasone and metoclopramide, to see which one works better at preventing nausea and vomiting after cataract surgery. Feeling sick or vomiting after surgery is common and can be very uncomfortable for patients. It can also cause delays in recovery and even serious complications, especially after eye surgery. The study hopes to find out if dexamethasone can reduce these problems more effectively than metoclopramide.

People between 40 and 80 years old who are generally healthy enough for surgery (based on a standard health rating called ASA I to III) may be able to join the trial. However, those who have a history of motion sickness, stomach problems, previous vomiting after surgery, or allergies to the study medicines cannot participate. If you join, you will receive one of the two medicines during your cataract surgery, and the medical team will monitor you afterward to see if the medicine helps prevent nausea and vomiting. This study is still looking for participants, so if you or a family member fits the criteria and are interested, you might want to ask your doctor about it.

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Eligibility criteria

• Inclusion Criteria:
• • Age: 40-80 years, both sexes.
• • ASA physical status class I to III.
• Exclusion Criteria:
• • history of motion sickness
• • patients with gastrointestinal disorders or gastro-oesophageal reflux
• • patients taking medications with known antiemetic activity
• • previous postoperative vomiting
• • allergy to bupivacaine
• • allergy to metoclopramide or dexamethasone