Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing

Launched by BEIRUT ARAB UNIVERSITY · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well a special medical glue called PeriAcryl helps heal the roof of the mouth (palate) after a small piece of tissue is taken for gum surgery. The researchers want to see if using PeriAcryl helps the tissue heal faster and if patients feel better about their healing compared to using a collagen sponge, which is another common treatment.

Adults between 18 and 74 years old who need this type of gum surgery and are generally healthy may be able to join. To be eligible, participants should not have serious health problems, should not smoke heavily, and should have good oral hygiene. During the study, participants will be randomly assigned to receive either the PeriAcryl glue or the collagen sponge on the wound site. The researchers will then follow up to check how well the area heals and how satisfied patients feel about their recovery. This trial is currently looking for volunteers and aims to find better ways to support healing after gum surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Low-moderate anesthetic risk (ASA I-II)
• • No restriction on ethnicity or gender
• • Patients requiring FGG from the palate for periodontal plastic surgery
• • Clinically healthy gingiva after phase I therapy
• • Full-mouth plaque index grades 0 and 1
• • Bleeding scores \<15%
• Exclusion Criteria:
• • Patients who smoke \> 10 cigarettes/day
• • Patients with coagulation disorders
• • Systemic diseases
• • Patients on certain medications that may affect periodontal tissues
• • Pregnant and lactating patient
• • Patients with allergies to drugs that will be prescribed during the treatment phase
• • Pathological mental conditions (dementia, psychosis) and lack of cooperation
• • Excessive gag reflex