A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition

Launched by PFIZER · Jul 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medicine called PF-07258669 to see if it is safe and how it works in older adults, especially those who might be at risk of poor nutrition or unintended weight loss. Unintended weight loss can happen when someone’s appetite decreases and they eat less, which can lead to health problems. This study aims to better understand how the medicine affects the body and whether it could help with this issue.

People who are between 60 and 90 years old, weigh at least 40 kg (about 88 pounds), and have a body mass index (BMI) of 25 or lower may be eligible to join. Participants should be men or women who cannot have children anymore and should not have serious health conditions or recent issues with alcohol or drug use. The study will last about 26 weeks and include visits to the doctor—some in person and some over the phone. Participants will answer questions and use simple devices at home to track things like blood pressure and physical activity. Throughout the study, the research team will closely monitor everyone’s health and well-being.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria Are 60 years to \<90 years Are males or females who can no longer have children Have Body weight ≥40 kg and Body mass index (BMI) ≤25 kg/m2 Exclusion Criteria Evidence or history of clinically significant medical conditions. Positive for active, untreated HIV, hepatitis B, and/or hepatitis C History of alcohol abuse or binge drinking and/or any other illicit drug use or dependence within 6 months of Screening.
• • Voluntary diet restriction or eating disorder