Alveolar Ridge Preservation Using Autogenous Whole Tooth Graft With 1 %Metformin :A Randomized Controlled Clinical Trial

Launched by CAIRO UNIVERSITY · Jul 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help preserve the shape and size of the jawbone after a tooth is removed. This is important because keeping the bone healthy and stable makes it easier to place a dental implant later on. The method being tested uses a special graft made from the patient’s own tooth combined with a low dose of a medication called metformin, which may help the bone heal better.

Adults aged 18 and older who need to have a single front or side tooth (not a molar) removed and have significant bone loss in that area might be eligible to join. However, people who are pregnant, smoke, have poor oral hygiene, certain infections, uncontrolled diabetes, immune problems, or are taking certain medications like bisphosphonates would not qualify. Participants can expect to have the tooth extracted and then receive this special graft treatment to help protect the bone. The study is not yet recruiting, but it aims to find better ways to keep the jawbone healthy after tooth removal, which can improve future dental implant success.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years or older
• • patients requiring single extraction of non-molar tooth
• • extraction sockets having more than 50% buccal alveolar bone loss
• Exclusion Criteria:
• • Pregnancy
• • smokers
• • patients not maintaing good oral hygiene
• • presernce of acute endodontic infection in the tooth to be ectracted
• • medical conditions hindering implant placement
• • uncontrolled diabetes
• • Immune suppression
• • bisphosphanates