The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy

Launched by JINQIAO QIAN · Jul 17, 2025

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ClinConnect Summary

This clinical trial is studying how a new anesthesia drug called remimazolam besylate affects breathing and brain function after surgery in older adults having a specific lung operation called thoracoscopic lobectomy. During this surgery, doctors often use a technique called one-lung ventilation, where only one lung is used to help with the procedure. This can sometimes cause low oxygen levels and problems with thinking and memory after surgery. The study aims to see if remimazolam can help improve oxygen levels during surgery and reduce these thinking difficulties afterward compared to other anesthesia drugs.

The trial will include patients aged 65 to 75 who are scheduled for this lung surgery and meet certain health criteria, such as having a body weight in a normal range and no serious heart, lung, or brain problems. Participants will be randomly assigned to receive either remimazolam alone, another common anesthesia drug called propofol, or a combination of both during their surgery. The researchers will closely monitor oxygen levels, brain function, and recovery after surgery, including pain, sedation, and any side effects. If you or a family member fit the criteria and are scheduled for this surgery at the First Affiliated Hospital of Kunming Medical University, you might be eligible to join and help improve care for future patients.

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Eligibility criteria

• Inclusion Criteria:
• • Patients scheduled for thoracoscopic surgery under general anesthesia at the First Affiliated Hospital of Kunming Medical University;
• • Age 65 to 75 years old;
• • BMI18-30 kg/m ²;
• • ASA grades I to III;
• • There are no contraindications to any related drugs;
• • Both the patient and their family members agreed to participate in this study and signed the informed consent form
• Exclusion Criteria:
• • Patients with severe sinus bradycardia (heart rate \<50 beats per minute) and atrioventricular block;
• • Respiratory tract infection and the use of non-steroidal anti-inflammatory drugs or hormone drugs within 2 weeks before the operation;
• • Those with central nervous system and psychological disorders;
• • Have taken anticholinergic drugs, anticonvulsants, anti-anxiety drugs, antidepressants, etc. in the past half year;
• • Severe liver and kidney dysfunction and immune system diseases, uncontrolled hypertension and diabetes;
• • History of preoperative radiotherapy and chemotherapy;
• • Patients with communication barriers who are unable to cooperate to complete the test;
• • The OLV \< 60 min or interim thoracotomy patients;
• • Intraoperative blood loss \> 1500ml;
• • Patients transferred to the ICU ward after the operation.