Cardiovascular Risk in Children With Chronic Conditions Study

Launched by SEMMELWEIS UNIVERSITY · Jul 17, 2025

Keywords

ClinConnect Summary

This study is looking at children and young adults with long-term health conditions that might raise their chances of heart and blood vessel problems early in life. The researchers want to understand why these problems happen and how tiny blood vessels in the body might already show signs of damage long before any serious heart issues appear. They also plan to use new computer technology, called artificial intelligence (AI), to help spot early warning signs and improve care tailored to each person’s needs.

The study is open to boys and girls aged 6 to 25 who have certain chronic health conditions, like kidney or liver transplants, diabetes, high blood pressure, obesity, or some types of cancer, among others. Participants need to agree to take part (or have a parent or guardian agree if they’re under 18). People with very serious health problems, ongoing chemotherapy, or certain infections won’t be able to join. If you take part, you can expect to have some tests and check-ups to help doctors learn more about heart health risks and how to catch problems early, so they can provide better care in the future.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • 1. Individuals aged between 6 and 25 years;
• • 2. Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease;
• • 3. Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study.
• • Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.
• Exclusion criteria:
• • 1. Severe intellectual and developmental disability;
• • 2. Decompensated heart failure;
• • 3. Severe primary immunodeficiency;
• • 4. Ongoing intravenous chemotherapy;
• • 5. Infectious diseases posing a public health risk; or
• • 6. History of regular alcohol or drug use.