Effects of Ketone Esters on Circulating Senescent T Lymphocytes (T Cells) and Inflammation Levels in the Elderly

Launched by FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY · Jul 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a substance called ketone esters, which are related to natural compounds your body makes during fasting or low-carb diets, might help reduce aging-related changes in the immune system and inflammation in older adults. Researchers want to understand if these ketone esters can protect the heart and improve overall health in people aged 65 to 80 who are generally healthy and do not have chronic diseases. This is important because as we age, certain harmful processes can affect the heart and immune cells, and ketone esters might offer a new way to prevent or treat these problems.

If you join the study, you can expect to be part of a group of older adults who will be monitored to see how their immune cells and inflammation levels respond to ketone esters. The study is currently looking for participants who have not recently used immune-suppressing drugs, have not had major diet changes, or undergone recent digestive surgery, and who do not have serious liver or kidney problems or cancer. This research could lead to new ways to help keep hearts healthier and reduce inflammation as people get older.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 65\~80 years old.
• • 2. The subjects are in good health, and no history of chronic diseases.
• Exclusion Criteria:
• • 1. Have used immunosuppressants or hormone drugs in the past six months.
• • 2. There has been a significant change in diet within the past month.
• • 3. Having digestive tract surgery within one year.
• • 4. Severe liver dysfunction (alanine aminotransferase level \> 3.0 upper limit of normal).
• • 5. Severe kidney dysfunction (creatinine clearance rate \< 30 mL/min).
• • 6. History of malignant tumor.