NYU Epilepsy Self-Management Study

Launched by NYU LANGONE HEALTH · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial at NYU is studying ways to help people with epilepsy feel better in their daily lives. Researchers are comparing two different support programs—called UPLIFT and PACES—to the usual care patients receive, to see if these programs can improve quality of life, reduce feelings of depression, and help control seizures over a year. The study is not yet enrolling participants but will include adults who have had epilepsy for at least one year.

To join, participants need to be adults who speak English or Spanish (Spanish speakers can join the UPLIFT program only) and be able to give informed consent. For the UPLIFT program, participants should have mild to moderate depressive symptoms but not severe depression or active suicidal thoughts. People with serious mental health conditions or significant memory problems will not be eligible. If you join, you’ll be randomly assigned to either one of the special programs or to enhanced usual care, and researchers will check in with you over 12 months to see how you’re doing. This study aims to find better ways to support people living with epilepsy and improve their overall well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (≥18 years)
• • English-speaking (UPLIFT and PACES) or Spanish-speaking (UPLIFT only).
• • Diagnosed with epilepsy for at least one year
• • Able to understand the informed consent and provide consent
• • Elevated depressive symptoms - Patient Health Questionnaire-9 (PHQ-9) score ≥10; applies to UPLIFT only
• Exclusion Criteria:
• • Severe depressive symptoms (score of ≥20 on PHQ-9)
• • Active suicidal ideation (score of ≥1 on PHQ-9 item #9 or otherwise reported during screening)
• • Active psychotic disorder (psychiatric diagnosis and/or antipsychotic medications in the electronic health records (EHR)
• • Significant cognitive impairment (indicated in the EHR or evident during screening)