Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases

Launched by XUANWU HOSPITAL, BEIJING · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help people with certain brain diseases that affect nerve function, like multiple sclerosis (MS) and similar conditions. These diseases cause problems with thinking and memory because they damage the protective covering of nerves in the brain and spinal cord. The study is testing a treatment called transcranial alternating current stimulation, which is a gentle, non-invasive method that uses small electrical currents applied to the head to improve brain function. Researchers want to see if this treatment can reduce symptoms and help with thinking difficulties in people with these conditions. They will also look at brain images and electrical activity to understand how the diseases affect the brain and who might benefit most from this treatment.

Adults between 18 and 60 years old who have been diagnosed with MS, neuromyelitis optica spectrum disorder (NMOSD), or similar inflammatory nerve diseases may be eligible to join, as long as their medications have been stable for at least three months. People who have had recent flare-ups, have metal implants like pacemakers, or other serious health issues may not qualify. Participants can expect to undergo brain stimulation sessions and various tests to monitor their brain activity and symptoms. The goal is to find ways to personalize this treatment in the future, making it more effective for each individual’s unique condition. This study is currently recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 18-60 years old.
• • Diagnosis: Patients with neuromyelitis optica spectrum disease, multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system that meet the diagnostic criteria.
• • Medications have been stable for at least three months.
• Exclusion Criteria:
• • Recurrence has been recorded in the past 3 months.
• • Have a pacemaker or other metal implant in the body.
• • Impaired skin integrity at the site of electrode placement.
• • Previous organic brain disease such as epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infection.
• • Combined with severe or unstable organic diseases, such as heart, liver and kidney and other organ dysfunction.
• • Pregnant or lactating women, those who are planning to become pregnant in the near future.
• • Patient compliance is poor.
• • In the opinion of the investigator, there is a situation that is not suitable to participate in this study.