Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Launched by PEKING UNIVERSITY FIRST HOSPITAL · Jul 25, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at kidney injury that can happen after a surgery called radical nephrectomy, where a kidney is removed. After this surgery, more than 40% of patients experience sudden kidney problems, called acute kidney injury (AKI). Right now, doctors use certain tests to detect AKI, like measuring substances in the blood and checking urine output, but these tests aren’t always quick or accurate. This study will explore new markers—signs in the body—that might better predict who will develop kidney problems right after surgery and who might have long-term kidney issues up to a year later.

Adults aged 18 and older who are scheduled to have one kidney removed (unilateral radical nephrectomy) may be eligible to join. People with only one kidney, very advanced kidney disease, or certain complications like tumor spread requiring more complex surgery won’t be able to participate. If you join the study, doctors will monitor these new markers before, during, and after your surgery to see if they can help predict kidney injury. This could lead to better ways to protect kidney health after surgery in the future. The trial has not started recruiting yet, so if you or a loved one is preparing for this surgery, it might be something to ask your doctor about soon.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Scheduled to undergo unilateral radical nephrectomy.
• Exclusion Criteria:
• • Solitary kidney;
• • Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \<30 mL/min/1.73m²);
• • Tumor invasion of the vena cava requiring thrombectomy;
• • Other conditions deemed by the investigator as unsuitable for participation in this study.