Effects of a GLP-1 Formula Drink on Gut Microbiota and Glycemic Control in Prediabetic Individuals

Launched by CHUNG SHAN MEDICAL UNIVERSITY · Jul 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a special drink containing a substance called GLP-1 can help people with prediabetes or who are overweight improve their blood sugar levels, cholesterol, body weight, and gut health. The researchers want to see if this drink can make a positive difference in managing early signs of diabetes and obesity by looking at changes in the bacteria living in the gut as well as important health markers.

Adults between 18 and 70 years old who have been told by a doctor that they have prediabetes (which means their blood sugar is higher than normal but not yet diabetic) or who have a body mass index (BMI) between 25 and 34.9, which is considered overweight or mildly obese, may be able to join. People with certain digestive diseases, autoimmune conditions, or serious mental health issues won’t be eligible, and pregnant or breastfeeding women cannot participate. If you join, you will be asked to drink the GLP-1 formula and have tests to check your blood sugar, cholesterol, body composition, and gut bacteria over time. This study is not yet open for participants, but it aims to help find new ways to support people at risk of diabetes and obesity through diet-based treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 18 to 70 years.
• • Clinically diagnosed with prediabetes (fasting plasma glucose: 100-125 mg/dL or HbA1c: 5.7-6.4%) or with a body mass index (BMI) of 25-34.9 kg/m², male or female.
• • Have not participated in similar clinical studies within the past three months.
• • Able to comprehend the informed consent form, including the study procedures, potential risks, and benefits, and able to provide written informed consent.
• Exclusion Criteria:
• • Diagnosed with autoimmune diseases or cancer.
• • Diagnosed with gastrointestinal chronic diseases such as irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, celiac disease, bowel control disorders, fecal incontinence, pancreatitis, peptic ulcer disease, colorectal cancer, short bowel syndrome, ulcerative colitis, lactose intolerance, or chronic diarrhea.
• • History of gastrointestinal surgery.
• • Planning pregnancy in the near future (including male partners), currently pregnant, or breastfeeding women.
• • Known allergy or hypersensitivity to probiotics or any of the study product ingredients.
• • History of major psychiatric disorders.
• • History of substance abuse or alcohol dependency.