Virtual Versus Dye-based Chromoendoscopy in Inflammatory Bowel Disease Surveillance Colonoscopy

Launched by UNIVERSITY HOSPITAL, LINKOEPING · Jul 22, 2025

Keywords

ClinConnect Summary

This study is looking at two different ways to examine the colon during routine check-ups for people with inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn’s disease. People with IBD have a higher chance of developing colon cancer, so regular colonoscopies are important to find any early changes that might lead to cancer. The study compares a traditional method that uses a special dye to highlight abnormal areas inside the colon with a newer method that uses advanced camera technology to do the same without needing any dye. The goal is to see if the newer, dye-free method works just as well at finding early signs of cancer.

Adults with IBD who have had the disease for at least 8 years and meet certain criteria—like having inflammation in a large part of the colon, having a related liver condition, or having a close family member with colon cancer—may be invited to join. Participants will have a regular colonoscopy as usual, but will be randomly assigned to one of the two viewing methods. There are no extra procedures, and the main difference is how the doctor looks inside the colon. The study will also observe how long the procedure takes, the number of tissue samples taken, any side effects, and how comfortable patients feel. Over time, researchers will follow participants’ health to see long-term results. This research aims to help doctors choose the best and most comfortable way to watch for colon cancer in people with IBD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Age ≥ 18 years and one of the criteria beneath:
• • Extensive ulcerative colitis or indeterminate colitis (IBD-U), or Crohn's colitis involving at least one-third of the colon, with a disease history of at least 8 years
• • IBD or IBD-U with primary sclerosing cholangitis (PSC)
• • IBD or IBD-U with a family history of colorectal cancer in a first-degree relative
• Exclusion Criteria:
• • History of colorectal cancer or prior colectomy
• • Contraindications to dye use
• • Colonoscopies for therapeutic purposes
• • Pregnancy
• • Inability to consent