Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Launched by VANDA PHARMACEUTICALS · Jul 22, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a medicine called Iloperidone to see if it can help people whose high blood pressure (hypertension) is not controlled well enough with their current treatment. The study aims to find out if Iloperidone is both safe and effective for lowering blood pressure in these patients.

People who might be eligible to join this study are adults between the ages of about 65 and 74 who have had high blood pressure readings of 130 mmHg or higher for the top number (systolic blood pressure) even after using one or more blood pressure medicines for at least eight weeks. However, people with very severe high blood pressure (a top number of 180 or higher), serious heart problems, or kidney issues will not be able to participate. Participants will be randomly assigned to receive either Iloperidone or a placebo (a pill with no medicine) without knowing which one they get, and the study will take place at multiple centers. This trial is not yet open for enrollment but aims to carefully check how well Iloperidone works and how safe it is for people with uncontrolled high blood pressure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies
• Exclusion Criteria:
• • Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency