Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

Launched by AGELESSRX · Jul 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying ways to help people keep the weight off after stopping certain weight-loss medications called GLP-1s (like Wegovy or Ozempic). Researchers want to see if taking other medicines—metformin alone, or combined with either rapamycin or low-dose naltrexone—can prevent weight from coming back after stopping GLP-1 medications. The study will follow participants for six months after they stop GLP-1s to compare how much weight they regain, along with other health measures like blood sugar and cholesterol levels, and how they feel overall.

If you’re between 40 and 85 years old, have been using GLP-1 medications for at least three months, and lost at least 15 pounds during that time, you might be eligible to join. Participants will take the assigned medicine as directed, share health information through surveys and wearable devices (like fitness trackers), and have blood tests every few months. The study aims to find out if these alternative treatments can help maintain weight loss and improve health after stopping GLP-1 drugs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Existing AgelessRx patient
• • Adults (40 - 85 years of age)
• • Any sex
• • Any ethnicity
• • BMI ≥ 22 kg/m\^2
• • Have been on GLP-1s (Wegovy, Ozempic, or a compounded form of GLP-1s) for at least three months before study initiation
• • Have lost at least 15 lbs during their GLP-1 use
• Exclusion Criteria:
• • Individuals who are denied a longevity product by the AgelessRx medical team will not be asked to participate in any product specific test(s) or questionnaire(s)
• • History of bariatric surgery
• • Use of weight-loss medications other than GLP-1s within the past 6 months
• • Age \<40 years
• • Contraindications to naltrexone, metformin, or rapamycin
• • Significant psychiatric illness that may affect participation
• • Pregnant or breastfeeding individuals