Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial

Launched by TRIBHUVAN UNIVERSITY TEACHING HOSPITAL, INSTITUTE OF MEDICINE. · Jul 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well two types of spinal anesthesia work for managing pain after a planned cesarean section (C-section). Specifically, it compares using a local anesthetic called bupivacaine alone versus bupivacaine combined with a small dose of morphine, given through a needle into the spine during surgery. The researchers want to find out if adding morphine helps control pain better and for a longer time after the operation.

Women who are having an elective (planned) C-section under spinal anesthesia and meet certain health criteria may be eligible to participate. To join, participants need to be adults in generally stable health without certain heart problems, infections, or allergies related to the medications used. During the trial, participants will receive either bupivacaine with morphine or bupivacaine alone during their surgery. Afterward, their pain levels and any side effects will be monitored for 24 hours, including noting how long it takes before they need extra pain relief. This study aims to help improve pain care for women after cesarean deliveries.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Parturients undergoing elective caesarean section under Spinal anesthesia
• • ASA PS II, III
• • \> 18 years
• Exclusion Criteria:
• • Refusal to Participate
• • Contraindications to spinal anaesthesia and adjuvants INR ≥ 1.5 Plateletes \< 1,00,000/cumm Severe aortic stenosis, and/or severe mitral stenosis Infection at lumbar puncture site Known allergy to local anesthetics and opioids
• • Communication barrier
• • Height \<150 cm