Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement

Launched by AIN SHAMS UNIVERSITY · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to manage pain after knee replacement surgery. Specifically, it compares using a combination of two types of nerve blocks—called IPACK and Adductor Canal Block—versus using the Adductor Canal Block alone. The goal is to see which method better reduces pain, helps patients recover movement in their knee, and lowers inflammation after surgery.

Adults between 20 and 70 years old who are having a total knee replacement may be eligible to join, as long as they are generally healthy enough for surgery (classified as ASA physical status I to III). People with certain health issues like severe kidney problems, nerve conditions, or infections near the knee won’t qualify. If you participate, you can expect to receive one of these nerve block treatments during your surgery and then have your pain levels, knee movement, and recovery monitored afterward. This study aims to find the best way to help patients feel better and regain movement more quickly after knee replacement.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing total knee replacement.
• • ASA physical status I to III
• • Sex (males and females).
• • Age 20 - 70 years.
• Exclusion Criteria:
• • Patients undergoing bilateral or revision total knee replacement.
• • ASA physical status more than III
• • Age less than 20 or older than 70
• • severe renal insufficiency ( Estimated Glomerular filtration rate eGFR \< 15 mL/min/1.73 m2 ).
• • history of arrhythmia or seizures.
• • Hypersensitivity to local anesthetics.
• • Preexisting peripheral neuropathy and prior vascular surgery on femoral vessels on operated site.
• • Infection near site of injection e.g. osteomyelitis, septic knee joint, etc.
• • Patient refusal or with difficulties in comprehending numeric pain rating scale (NRS) pain scores
• • Any contraindications for spinal anesthesia. (eg.: refusal of patients, coagulopathy, use of anticoagulants or antiplatelets...)