Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D

Launched by BANGLADESH MEDICAL UNIVERSITY · Jul 24, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether taking vitamin D3 supplements can improve brain activity in men who have epilepsy and low levels of vitamin D. Researchers will measure brain waves using a special test called a quantitative electroencephalogram (QEEG) before and after giving vitamin D3 for 8 weeks. The goal is to see if vitamin D3 helps brain function in these patients.

Men who have been diagnosed with epilepsy, have low vitamin D levels (below 30 ng/ml), and are taking certain epilepsy medications may be eligible to join. Participants need to be in generally good health, with a body weight in a healthy range, and not taking other medications that affect the brain. During the study, participants will take a weekly vitamin D3 pill for 8 weeks and then return to the clinic for blood tests and brain wave measurements. They will also need to bring back the empty vitamin D packaging to confirm they took the supplements. This study is currently recruiting and aims to better understand how vitamin D might support brain health in men with epilepsy.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed male patients with Epilepsy by neurologist from the Out Patient Department of Department of Neurology, BMU by taking proper history of at least two unprovoked (or reflex) seizures occurring \> 24 hours apart, from patients and eye witnesses.
• • Hypovitaminosis D (\<30 ng/ml)
• • BMI : 20 - 24 kg/m²
• • On antiepileptic medication for 6 months to 2 years (enzyme inducing AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital)
• • Without any medication that affect central nervous system other than antiepileptic drugs (Antidepressants, Antipsychotic, Anxiolytic, Anesthetic drugs)
• • Apparently normal physical health
• Exclusion Criteria:
• • Patients suffering from absence seizure
• • Certain AEDs (Sodium valproate, Ethosuximide, Oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam)
• • Smoker
• • Alcoholic
• • Known hypersensitivity to vitamin D3
• • Patients with hypertension
• • Patient with Thyroid disorder
• • Patient with Diabetes mellitus
• • Patient with Renal Disease
• • Patient with liver Disease
• • Patient with hypercalcemia