Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy

Launched by HENAN PROVINCIAL PEOPLE'S HOSPITAL · Jul 30, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how well two pain medicines, Oliceridine and Oxycodone, work to relieve pain and how safe they are for people having a vitrectomy, which is a type of eye surgery. Both medicines are opioids, commonly used for moderate to severe pain, but they can sometimes cause side effects like low blood pressure, breathing problems, nausea, or itching. This study aims to find out if Oliceridine might offer effective pain relief with fewer side effects compared to Oxycodone during and after the eye surgery.

People who may join this study are adults between 18 and 75 years old who are scheduled for vitrectomy under local anesthesia (numbing around the eye) combined with sedation (medicine to help them relax). Participants should be generally healthy without serious heart, lung, liver, or kidney problems and must not be allergic to opioids or have a history of opioid misuse. Before surgery, their pain levels should be low, and they must be able to communicate clearly about their pain and comfort. If accepted, participants will receive one of the two medicines during their surgery and be closely monitored for pain relief and any side effects. This trial is not yet recruiting, but it hopes to help improve pain treatment for people undergoing this common eye operation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-75 years old, ASA Ⅰ - Ⅱ (the age of patients with vitreous surgery can be relaxed to 75 years old, and serious systemic diseases need to be excluded);
• • Vitrectomy with local anesthesia (retrobulbar / peribulbar block) combined with intravenous sedation and analgesia (such as maculopathy, retinal detachment, etc.);
• • Preoperative VAS score ≤ 3, can cooperate with pain and sedation score;
• • Signed informed consent.
• Exclusion Criteria:
• • Be allergic to test drugs or opioids, or have a history of opioid abuse;
• • Severe cardiopulmonary disease (such as heart failure, COPD), liver and kidney dysfunction (alt/ast \> 3 times normal, creatinine \> 177 μ mol/l);
• • Glaucoma (avoiding the risk of fluctuation of intraocular pressure), sinus bradycardia (\< 50 beats / min, preventing aggravation of oculo cardiac reflex);
• • Used analgesic / sedative drugs within 24 hours before surgery;
• • Those who are unable to cooperate due to mental illness or cognitive impairment.