An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

Launched by LATIGO BIOTHERAPEUTICS · Jul 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medicine called LTG-001 to see if it can help reduce pain after a tummy tuck surgery (called abdominoplasty). The study wants to find out how well LTG-001 controls pain during the first 48 hours after surgery, how safe it is to use during that time, and which dose works best for pain relief.

People who might join the study are adults between 18 and 50 years old who are scheduled for a partial tummy tuck under general anesthesia, have a body weight within a certain range, and meet some health and lifestyle requirements. Participants will take LTG-001 twice a day after their surgery and stay at the clinic for about 48 hours to be monitored. They will also return two weeks later for a safety check. During the study, they will report how their pain changes so researchers can see if the medicine is helping. This study is currently recruiting volunteers and welcomes both men and women who fit the criteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject is male or female aged 18 to 50 years
• • Scheduled to undergo an elective "partial" abdominoplasty under general anesthesia
• • Has a body BMI 18.0 to 35 kg/m2
• • Has signed informed consent and will comply with the requirements and restrictions of the study
• • Meet lifestyle, medication, or other study restrictions
• • Subject must agree to study required use of birth control
• • Post-surgical (abdominoplasty) pain must meet the study threshold
• Exclusion Criteria:
• • Inability to take oral medications
• • Prior abdominoplasty or a prior intra-abdominal and/or pelvic surgery (including hysterectomy and Cesarean section) that resulted in any complications
• • History of impaired hepatic function or heart disease.
• • Abnormal liver laboratories or other lab abnormality indicative of serious medical condition
• • Sensory abnormality that would confound post-surgery pain assessments
• • Chronic use of NSAIDs, benzodiazepines, opioid use within the last year, use of medications that prolong QTc intervals, or other dietary and medication restrictions
• • A subject with sleep apnea and/or on a home continuous positive airway pressure machine.
• • Positive drug screen.