Therapeutic Effect of Microfragmented Adipose Tissue (Lipogems) Injection on Maximum Interincisal Opening Versus Injectable Platelet-rich Plasma (PRP) for the Treatment of Anterior Disc Displacement With Reduction : A Randomized Clinical Trial

Launched by CAIRO UNIVERSITY · Jul 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for a jaw joint problem called TMJ disc disorder, which can cause pain, clicking sounds, and difficulty opening the mouth fully. The researchers want to see if injecting a special type of fat tissue taken from the patient’s own body (called microfragmented adipose tissue) into the jaw joint can reduce pain and improve jaw movement better than the current treatment, which uses a substance made from the patient’s own blood called platelet-rich plasma (PRP).

People who might be eligible for this study are those who have symptoms like jaw pain, limited mouth opening, or clicking sounds in the joint, and have been diagnosed with TMJ disc displacement using an MRI or physical exam. Participants in the trial will receive a procedure where fluid is washed through the joint to remove inflammation and then receive an injection either of the microfragmented fat tissue or PRP. The goal is to help reduce pain and improve jaw function. However, people with certain health conditions, such as blood or nerve disorders, connective tissue diseases, metal implants, or those who cannot cooperate with the procedure, will not be eligible. This study is not yet recruiting, and further research will be needed to confirm long-term benefits.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients should have one or more signs and symptoms of these
• • Disc displacement assessed by clinical examination and MRI
• • Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.
• • Mouth Opening: Limited range of motion or difficulty with full mouth opening .
• • Clicking: Audible clicking.
• • Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck.
• Exclusion Criteria:
• • Previously diagnosed hematological and neurological conditions;
• • Previous malignant head and neck neoplasms;
• • Contraindication to fat harvesting.
• • Uncooperative patients.
• • connective tissue disorders.
• • a pacemaker or any other metal prosthesis in the body.