Necrotizing Soft Tissue Infections
Launched by EUROPEAN SOCIETY FOR TRAUMA AND EMERGENCY SURGERY · Aug 4, 2025
Trial Information
Current as of August 19, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Necrotizing soft-tissue infections (NSTIs) are life-threatening surgical emergencies with high mortality despite timely surgical debridement and antibiotic treatment. Wide variability in treatment strategies-ranging from diagnostic imaging to operative timing and adjunctive therapies-contributes to outcome heterogeneity, yet no standardized, high-resolution prospective data exist to guide best practices.
SnapNSTI is a time-bound, multicenter international observational cohort study coordinated by the Center for Emergency Surgery Outcomes Research (CESOR) at the University of Pennsylvania, ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age ≥18 years
- * Diagnosis of necrotizing soft-tissue infection (NSTI) confirmed by:
- • Surgical or histopathological evidence of fascial necrosis
- • OR imaging showing gas in the fascial plane
- • Admitted to a participating hospital during the enrollment period
- Exclusion Criteria:
- • Non Severe soft-tissue infection
- • Patients \<18 years old
About European Society For Trauma And Emergency Surgery
The European Society for Trauma and Emergency Surgery (ESTES) is a leading professional organization dedicated to advancing the field of trauma and emergency surgery through research, education, and collaboration. Committed to improving patient outcomes, ESTES facilitates clinical trials and innovative studies that enhance the understanding and treatment of traumatic injuries and acute surgical conditions. The society brings together experts from various disciplines to foster knowledge exchange, establish best practices, and promote evidence-based approaches in emergency care. Through its initiatives, ESTES aims to set standards for trauma management and contribute to the global advancement of surgical practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Barcelona, , Spain
Patients applied
Trial Officials
Gary A Bass, MD PhD
Study Chair
University of Pennsylvania
Ana Maria González Castillo, MD PhD
Principal Investigator
Hospital del Mar
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported