Cost-effectiveness Analyses for the Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery in the UK

Launched by THE ROYAL WOLVERHAMPTON HOSPITALS NHS TRUST · Aug 5, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how cost-effective different approaches are in preventing acute kidney injury (AKI) in patients who have heart surgery in the UK. AKI is a condition where the kidneys suddenly stop working properly, which can sometimes happen after heart surgery. The study will analyze past data from multiple hospitals to compare patients who developed AKI after surgery with those who did not, to better understand which prevention methods might offer the best value and outcomes.

Patients who had planned or urgent heart surgery using a heart-lung machine (called cardiopulmonary bypass) between 2013 and 2023 may be included, as long as their medical records have complete information needed for the study. Emergency surgeries, patients already on dialysis, or those with very poor kidney function before surgery will not be part of this study. Since this is a review of existing data, participants won’t need to undergo any new treatments or visits. This study is not yet recruiting, but it aims to help doctors make better decisions to protect kidneys during heart surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing cardiac surgery (elective or in-house urgent) from Jan 1st, 2013, to December 31st, 2023 (excluding patients during 2020 \& 2021 - due to confounding Covid-19 impact on AKI)
• • 2. Cardiopulmonary bypass machine was used during cardiac surgery
• • 3. Patient's data available in the databases (Minimum dataset required for propensity matching: age, gender, diabetes history, LVEF, priority of surgery, pre-op haemoglobin \& SCr levels, cardiac surgery performed, CPB duration, Euroscore or LogEuroscore, RRT use, post-op D1\&/or D2 \&/or D3 SCr)
• Exclusion Criteria:
• • 1. Emergency surgery
• • 2. Patient with incomplete dataset\*
• • 3. Surgery performed without CPB
• • 4. Patients already dialysis dependent
• • 5. Patient with eGFR \<20 mL/min/1.73 m²
• • 6. Cardiac surgery requiring deep hypothermic circulatory arrest (DHCA)
• • 7. Patients previously treated with RenalGuard® Therapy
• • 8. Patient has opted-out of research (data opt-out) \* Data completeness - These variables need to be complete for the propensity matching: age, gender, diabetes history, LVEF, priority of surgery, pre-op haemoglobin \& SCr levels, cardiac surgery performed, CPB duration, Euroscore or LogEuroscore, RRT use, post-op D1\&/or D2 \&/or D3 SCr