A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Jul 31, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new tool designed to help doctors predict how patients with serious lung infections, like pneumonia or sepsis, might recover over time. The goal is to see if this prediction model can accurately forecast how these patients will do, which could help guide their treatment. The study will take place at one medical center and will follow patients over about a month, checking their health status on the day they join, then again on day 7 and day 28.

People who might join the study are adults diagnosed with either community-acquired pneumonia (a lung infection caught outside the hospital) or sepsis (a severe reaction to infection). To be eligible, participants need to be 18 or older, able to follow study visits, and meet specific medical guidelines for their condition. During the study, participants will have blood samples taken at each visit to help test how well the prediction tool works. The study is not yet recruiting participants, and certain people, such as those with serious heart or liver problems, pregnant women, or those with recent major heart events, will not be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Community-acquired pneumonia group
• • Age ≥18 years old;
• • Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit; ④ Comply with the diagnostic criteria for community-acquired pneumonia in the Chinese Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Adults (2016 Edition); ⑤ The time from onset to enrollment was ≤8 days. Sepsis Group
• • Age ≥18 years old;
• • Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit;
• • Patients who meets the sepsis 3.0 diagnostic criteria.
• Exclusion Criteria:
• • Exclusion criteria
• • Respiratory failure related to underlying heart and lung diseases;
• • Severe liver and kidney dysfunction, pregnancy or lactation period;
• • Meet the indications for organ transplantation or have undergone organ transplantation surgery in the past; ④ Known HIV infection; ⑤ Screening: Those who have experienced unstable angina pectoris or myocardial infarction within 30 days prior to the screening and have not received vascular recanalization treatment, as well as those with extensive cerebral hemorrhage; ⑥ Situations where researchers determine that enrollment is not appropriate.