Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers

Launched by MEDICAL UNIVERSITY OF GRAZ · Jul 31, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a natural extract from the Boswellia serrata plant, which has been used in traditional medicine for its anti-inflammatory and pain-relieving properties, affects different types of pain sensitivity in healthy adults. The researchers want to understand if Boswellia serrata can reduce pain by acting on the nervous system, using a special test that safely causes temporary pain to study how the body responds. They will also look at whether taking Boswellia serrata has any effects on mood, sleep quality, and overall well-being.

Adults aged 18 and older who do not have chronic pain, major health problems, or certain medication restrictions may be eligible to participate. Participants can expect to take either Boswellia serrata or a placebo (a harmless inactive substance) in a randomized order, and undergo tests that measure their sensitivity to pain and their nervous system’s response. The study is non-invasive, meaning it does not involve surgery or permanent changes, and uses questionnaires to check mood and sleep. This trial aims to better understand how Boswellia serrata might help with pain, which could benefit future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: ≥18 years
• Exclusion Criteria:
• • Not pregnant or breastfeeding
• • No renal or liver insufficiency
• • No neurological/dermatological/cardiovascular diseases
• • No chronic pain and/or use of analgesics
• • No use of anticoagulants
• • No use of antidepressants
• • No use of MAO inhibitors
• • No use of St. John's Wort
• • No use of medications affecting the CYP mechanism
• • No allergies to Boswellia serrata or capsaicin"