Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment

Launched by MANSOURA UNIVERSITY · Aug 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well four different treatments can help repair early tooth decay, called white spot lesions, on the surface of permanent teeth. These white spots are the first signs of tooth decay where the enamel (the hard outer layer) starts to break down but hasn’t formed a cavity yet. The study will follow participants for two years to see which treatment works best at restoring the enamel and stopping the decay from getting worse.

People between the ages of 14 and 26 who have at least one visible white spot on the front or side surface of their permanent teeth may be eligible to join. Participants need to have good oral hygiene and must agree to take part in the study (or have a parent or guardian agree if under 18). Those who have recently used certain medications that stain teeth or had fluoride treatments within the last three months won’t be able to participate. During the study, participants will receive one of the four treatments and have their teeth checked regularly to monitor how well the enamel is healing. This trial aims to find better ways to protect and improve early tooth decay before cavities develop.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants should have at least one visible initial enamel caries in the permanent teeth
• • Only lesions with ICDAS II score of 1 or 2 could be included
• • The patients must have good oral hygiene
• Exclusion Criteria:
• • patients receiving tetracyclines, any other medication known to stain teeth - Patients had fluoride application less than 3 months before the study
• • Teeth which have microcavities or dentinal involvement due to loss of enamel - Teeth that have discoloration, enamel hypoplasia or fluorosis.