Effectiveness of NOA OATMAD

Launched by UNIVERSITY OF ALBERTA · Aug 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well a custom-made mouthpiece called the OrthoApnea NOA helps people with obstructive sleep apnea (OSA), a condition where breathing repeatedly stops and starts during sleep. Many people with OSA use a CPAP machine to help them breathe at night, but some find it uncomfortable. This study is testing whether the NOA mouthpiece can be an easier and more comfortable option to reduce the number of breathing interruptions during sleep. The study also looks at a small device called the Morning Aligner, worn briefly each morning, which may help move the jaw back into a better position to reduce side effects and improve comfort.

The study will include adults aged 65 to 74 who have been diagnosed with OSA and are using the NOA mouthpiece for treatment. Participants will be followed for up to three years to see how well the NOA reduces breathing pauses, aiming to cut them by at least half and reach fewer than five per hour, which is close to normal. Researchers will also check oxygen levels during sleep, daytime sleepiness, comfort, durability of the mouthpiece, and how often people continue to use it. Instead of randomly assigning treatments, this study compares new patients using the NOA to past patients who used other types of mouthpieces, reflecting real-life use. This approach will help doctors and patients understand how the NOA works over time and how it compares to other options for treating sleep apnea.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Dxed OSA being treated with NOA appliance
• Exclusion Criteria:
• • no OSA Dx