Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

Launched by CAMPBELL CLINIC · Aug 4, 2025

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ClinConnect Summary

This clinical trial is studying whether taking an oral medicine called tranexamic acid (TXA) after surgery can help improve recovery for young people who have had ACL reconstruction—a common knee surgery to fix a torn ligament. The study will compare patients who take TXA pills for 10 days after surgery to those who take a placebo (a dummy pill), to see if the medicine helps reduce pain and improve knee function during healing.

The trial is for adolescents and young adults aged 14 to 22 who are having their first ACL surgery using a specific type of tendon from their own knee. Participants will receive standard care during surgery, including IV TXA, and then start taking either the TXA pills or placebo the day after surgery. They will be closely followed for up to two years to check on pain levels, knee movement, muscle strength, and how quickly they can return to sports. People with certain other knee injuries, previous blood clots, allergies to TXA, or using some types of birth control won’t be eligible. If you or someone you know fits these criteria and is interested, this study might offer a way to help improve recovery after ACL surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 14-22 year old individuals with ACL tear undergoing primary ACLR with patellar tendon autograft.
• • Closed or closing proximal tibial and distal femoral physes on pre-operative radiographs (less than one year of growth remaining based on MRI and radiographic bone age assessment)
• • Fluent in English
• • Willing to participate
• • Patient weight greater than or equal to 100lbs (45.4kg)
• Exclusion Criteria:
• • Revision ACLR, multi-ligamentous knee reconstruction, inclusion of lateral extra-articular tenodesis (LET) or Anterolateral Ligament (ALL) reconstruction
• • Concomitant meniscal repair or chondral preservation surgery requiring postoperative limited weightbearing status (nonweightbearing or partial weightbearing)
• • Have a prior history of deep vein thrombosis (DVT) or thromboembolic event
• • Known allergy or hypersensitivity to TXA
• • Using combination hormonal contraception