Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring

Launched by XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY · Aug 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how to better predict outcomes for patients with serious brain injuries, such as severe strokes, bleeding in the brain, or traumatic brain injuries. The researchers plan to use different types of brain monitoring tools together—like tests that measure brain activity, blood flow, and oxygen levels—to create a model that can help doctors understand a patient’s chances of waking up, remaining in a coma, or passing away within 90 days. This model aims to support doctors in making more personalized treatment decisions for patients in intensive care.

People who may be eligible to participate are adults between 18 and 80 years old who have recently suffered a severe brain injury and are admitted to the ICU with very limited eye and motor responses, meaning they are not opening their eyes and have little or no movement. Participants must be able to undergo continuous brain monitoring for at least three days. The study only observes patients and does not involve any new treatments or procedures. Families or legal representatives will be asked to give consent before participation. This study is not yet recruiting but hopes to help improve how doctors predict recovery for patients with critical brain injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18-80 years, no gender restrictions.
• • 2. Diagnosed with acute brain injury (ABI), including one of the following: large cerebral infarction, supratentorial large-volume intracerebral hemorrhage, subarachnoid hemorrhage, or severe traumatic brain injury, with imaging evidence (CT or MRI) supporting the diagnosis.
• • 3. On ICU admission, Glasgow Coma Scale (GCS) eye response = 1 (no eye opening) and motor score ≤ 5 (does not follow commands); or within 48 hours, neurological deterioration with no eye opening and motor score reduced to ≤ 5 (total GCS score ≤ 8).
• • 4. Able to undergo continuous multimodal monitoring, with an expected ICU stay of ≥72 hours.
• • 5. Informed consent signed by the family or legal representative.
• Exclusion Criteria:
• • 1. Confirmed brain death on admission or imaging showing irreversible brain herniation.
• • 2. Severe trauma unrelated to brain injury (e.g., multiple fractures, spinal cord injuries, or visceral rupture) that may interfere with brain function monitoring or outcome assessment.
• • 3. Pre-existing severe neurological disorders such as epilepsy, severe encephalopathy, or chronic intracranial conditions (e.g., brain tumors or hydrocephalus).
• • 4. Inability to perform multimodal monitoring due to technical issues (e.g., equipment failure or sensor installation problems).
• • 5. Predicted survival time \<24 hours after admission, or family members choose to withdraw treatment.
• • 6. Refusal to participate in the study by the patient or their legal representative.